Enhanced Guidance for Transferring a Cell Counting Method from Vi-CELL XR to Vi-CELL BLU Cell Viability Analyzers
This application note provides a structured workflow for laboratories transitioning from Vi-CELL XR to Vi-CELL BLU cell viability analyzers, helping align results for Total Cell Density (TCD) and Viability between the two platforms.
The recommended migration workflow includes the following steps:
- Verify instrument performance using concentration control beads and L10 size controls
- Optimize Vi-CELL BLU analyzer cell type parameters through visual review of algorithm annotations
- Establish a Concentration Adjustment Factor using easy-to-analyze samples run on both Vi-CELL XR and Vi-CELL BLU instruments
- Compare results and adjust Vi-CELL BLU analyzer cell types to align with Vi-CELL XR analyzer cell types, if needed
- Validate Vi-CELL BLU analyzer cell type settings for alignment to historical Vi-CELL XR analyzer results
The workflow supports up to 3 Vi-CELL BLU analyzers and 3 Vi-CELL XR analyzers. For best results, Vi-CELL BLU analyzer software version 2.0 or later is recommended.
Authored by Julie Lutti, Systems Engineer, and Andrew Wu, Senior Applications Scientist — Beckman Coulter Life Sciences.
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