Streamlining characterization and monitoring of oligonucleotide impurities using an Orbitrap-based LC-HRAM-MS platform
Aims of this whitepaper
- Demonstrate the use of BioPharma Finder 5.1 software for impurity identification and
sequence mapping using ddMS 2 data collected on the Orbitrap Exploris 240 mass
spectrometer - Demonstrate the use of Chromeleon CDS 7.3.1 software for relative quantitation of
FLP and impurities using full MS data collected on the Orbitrap Exploris MX mass
detector - Demonstrate the use of the Chromeleon eWorkflow procedure for direct method
transfer between Orbitrap Exploris-based LC-HRAM-MS instruments for quantitative
impuritiy analysis
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