Quantitative Analysis of Warfarin Tablets Containing Salt-Form Impurities Using Transmission Raman Spectroscopy
This Application Note demonstrates the use of transmission Raman spectroscopy (TRS) for the quantification of Warfarin in whole intact pharmaceutical tablets at 0.5 % w/w with 20 second measurement time1 . TRS can differentiate between and quantify two forms of Warfarin without sample preparation. Traditional chromatography techniques cannot do this as the form information is destroyed by solvation. TRS enables fast, automated, nondestructive quantitative bulk analysis of pharmaceutical oral solid dose forms for content uniformity and polymorph analysis.
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