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Minimum Sample Weights According to USP <41>, OIML R 76 and EURAMET cg-18

Minimum Sample Weights According to USP <41>, OIML R 76 and EURAMET cg-18

 

Minimum Sample Weights According to USP

Regulatory clarity. Metrological confidence. Process-ready recommendations.

Accurate weighing isn’t just about calibration—it’s about knowing the smallest sample you can trust. Sartorius’ expert white paper walks you through the core concepts behind minimum sample weight and how to apply leading standards—USP <41>, OIML R 76 and EURAMET cg-18—to ensure every result is valid, traceable, and fit for purpose.

What you’ll learn:

  • Why small samples carry high uncertainty—and how to calculate minimum sample weights for reliable results.
  • How leading standards differ:
    • USP <41>: Requires on-site repeatability tests and sets minimums based on statistical variance.
    • OIML R 76: Applies fixed regulatory thresholds by accuracy class for legal metrology use.
    • EURAMET cg-18: Allows custom limits based on your process accuracy and chosen safety factor.
  • What values apply to your Sartorius balance: The guide includes real minimum sample weights (smallest, typical, and recommended) for dozens of Cubis® II models.
  • How to use built-in tools like the SQmin function to enforce compliance directly at the balance interface (see page 7 image of Secura® display).

Why it matters:

  • In pharma, diagnostics and regulated labs, weighing below minimum sample weight can invalidate results.
  • A difference of just a few milligrams could cause a 10% error at microbalance scale.
  • As shown in Figure 3 (page 5), uncertainty rises sharply with lower weights—requiring robust margins and awareness of risk.

Practical tools. Trusted standards. Backed by science.

From simple OIML tables to advanced calibration via EURAMET cg-18, this paper is your complete guide to safe, compliant weighing. Whether for daily SOPs or auditor-ready documentation, Sartorius helps you weigh smart from the start.

Download the white paper and get your weighing workflows fully aligned with USP and Ph. Eur. compliance today.

White Paper from  Sartorius_Logo Brought to you by: analytical_logo

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