Reducing running costs for GC-MS/MS analysis of pesticide residues using hydrogen carrier gas

Helium is the standard carrier gas for gas chromatography thanks to its high chromatographic efficiency and inertness. This is particularly important when considering applications involving mass spectrometric detection (GC-MS), where these characteristics ensure the best performance in terms of sensitivity. This has resulted in well-established, validated, and regulated GC and GC-MS methods using helium as the carrier gas. However, helium is a limited and non-renewable natural resource,1 and recent price increases and supply issues caused by shortages have led laboratories and instrument manufacturers to investigate possible mitigation options, such as switching to alternative carrier gases or reducing the consumption of helium.

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