Towards Greener GPC/SEC

As a liquid chromatography (LC) technique, gel permeation chromatography/ size‑exclusion chromatography (GPC/SEC) requires the use of a mobile phase. The growing awareness of the need for more sustainable (greener) solutions has focused attention on environmentally- and health-friendly solvents and solutions. Three of the well-known 12 principles of green chemistry1 are central requirements for liquid chromatography: waste prevention, safer solvents and auxiliaries, and use of renewable feedstocks. Many scientists are currently concerned with the question of how to implement these principles in the analytical laboratory. This white paper discusses less hazardous solvent alternatives from renewable resources that can be successfully applied for size separation of macromolecules. Options are also presented for GPC/SEC users to establish solutions that align with the 12 principles of green chemistry.

White Paper from